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pentobarbital will minimize the level or influence of verapamil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lower the extent or outcome of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not advised; strong cytochrome P450 enzyme inducers